Zakład Biologii Molekularnej, Wydział Biologii, Uniwersytet

Anti-Topoisomerase I Rabbit Polyclonal Antibody VWR

The 1531-amino acid protein is a member of the Type II topoisomerase family. The cellular localization is predicted to be cytoplasmic and nuclear. A nice clip i found on the mechanisms of action of topoisomerase 1 and 2 Anti-topoisomerase antibodies (ATA) are directed against topoisomerase and found in several diseases, most importantly scleroderma. Diseases with ATA are autoimmune disease because they react with self-proteins.

Among these antibodies Anti-topoisomerase I antibodies (also called anti-Scl-70 antibodies) are directed against different epitopes on this enzyme (Simon et al., 2009). Although they are considered highly specific to SSc, recent studies demonstrated the presence of these antibodies in the sera of rare healthy patients as well as patients with systemic lupus erythematosus (SLE) (up to 25%) ( Spencer-Green et al Topoisomerases are enzymes that participate in the overwinding or underwinding of DNA. The winding problem of DNA arises due to the intertwined nature of its double-helical structure. During DNA replication and transcription, DNA becomes overwound ahead of a replication fork. If left unabated, this torsion would eventually stop the ability of DNA or RNA polymerases involved in these processes to … Western blot - Anti-Topoisomerase II beta/TOP2B antibody (ab72334) All lanes : Anti-Topoisomerase II beta/TOP2B antibody (ab72334) at 0.04 µg/ml. Lane 1 : Whole cell lysate from Hela cells at 50 µg.

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The anti-topoisomerase I antibodies (anti-topo I and anti-. Scl70) are serological markers of diffuse systemic sclerosis.

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Systemic sclerosis (SSc) is a multisystem disorder of connective tissue characterized by excessive fibrosis in the skin and various internal organs. INTRODUCTION: In the present study, the detection of anti-topoisomerase I (anti-topo I) autoantibodies was evaluated for diagnosis and risk assessment of systemic sclerosis (SSc) patients in a well characterized large monocentric cohort. Using immunoprecipitation assays and enzyme-linked immunoassay (ELISA), anti-topoisomerase I Ab was detected in 53 SSc patients who visited Kanazawa University Hospital between 2001 and 2010. In these patients, the association between serum anti-topoisomerase I Ab levels measured with ELISA and clinical features were compared using univariate analysis and multiple regression analysis. English.

Avhandling: Studies on anti-leukemic terpenoids from medicinal mushrooms and membrane potential (MMP) and inhibition of topoisomerase IIα expression. Antikroppsbehandlingen ges under tolv månader varav i regel två månader paral- lellt med cytostatika. Den hormonella behandlingen av. HER2-positiv och ER- Diffuse cutaneous systemic sclerosis exhibits production of anti topoisomerase I antibodies (anti Scl 70)
and skin lesion affects also proximal parts of the Anti-topoisomerase antibodies (ATA) are autoantibodies directed against topoisomerase and found in several diseases, most importantly scleroderma. Diseases with ATA are autoimmune disease because they react with self-proteins. They are also referred to as anti-DNA topoisomerase I antibody (anti-topo I). Topoisomerase inhibitors are chemical compounds that block the action of topoisomerases, which are broken into two broad subtypes: type I topoisomerases (TopI) and type II topoisomerases (TopII).
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Lane 3 : Whole cell lysate from Hela cells at 5 µg. These include antiphospholipid antibodies 76,77 and other nuclear antigens. 78 Anti-topoisomerase antibodies are usually associated with scleroderma but can be found in up to 7.7% of patients with SLE; however, the titers are higher in scleroderma. 79 Scleroderma and SLE fit within the same spectrum of interferon-mediated disease, and a subset of patients with scleroderma, as well as anti-topoisomerase and anti–U1 ribonucleoprotein (anti–U1-RNP) antibodies, show a lupus-like high This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility. - Improved sensitivity and specificity.

CITR. Anti-CCP (ACPA): 95% specificitet för RA, 60-80% sensitivitet. ACPA (anti-CCP): Anti Citrullinated Protein Antibody. Klassificeras utifrån verkningsmekanism, delas in i 1) Alkylerande medel och platinaföreningar 2) Topoisomeras-hämmare 3) Antimetaboliter 4) Mitoshämmare (SLE), Sjögrens syndrom, systemisk skleros och myosit/anti-syntetassyndrom. Topoisomeras-1 (Scl-70), centromerantigen B (CENP-B), och Jo-1 (samtliga RF, anti-CCP, extraartikulära symptom etc.
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Lane 2 : Whole cell lysate from Hela cells at 15 µg. Lane 3 : Whole cell lysate from Hela cells at 5 µg. These include antiphospholipid antibodies 76,77 and other nuclear antigens. 78 Anti-topoisomerase antibodies are usually associated with scleroderma but can be found in up to 7.7% of patients with SLE; however, the titers are higher in scleroderma. 79 Scleroderma and SLE fit within the same spectrum of interferon-mediated disease, and a subset of patients with scleroderma, as well as anti-topoisomerase and anti–U1 ribonucleoprotein (anti–U1-RNP) antibodies, show a lupus-like high This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility.

Anti Cancer properties of TheraCIM®: Antiproliferative activity. Antiangiogenic activity. Pro-apoptotic activity. Mediates complement-dependent cytotoxicity ( CDC) Jun 22, 2019 For instance, Topoisomerase type1 cut one strand of DNA and Topoisomerase type 2 cut both strands of DNA so relax the coil. By making sure, Rabbit IgG polyclonal antibody for Topoisomerase I detection. Tested with WB, Direct ELISA in Human;Mouse;Rat.Hundratusentals antikroppar är tillgängliga Rabbit Polyclonal Topoisomerase II alpha/TOP2A Antibody. Validated in WB and tested in Human.
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Prediction of organ involvement and survival in systemic

Different antibodies, called anti-topoisomerase and RNA polymerase III, are often present in people who have diffuse systemic sclerosis. Thus, the diagnosis of systemic sclerosis is based on all of the information doctors gather, including symptoms, physical examination results, and all test results. Some antibodies are considered highly specific for SSc, including Scl-70 (anti-topoisomerase 1) antibody, anti-centromere (CENP) antibodies, and anti-RNA polymerase III antibody and are classification criteria for disease defined by the American College of Rheumatology. Quest testing detects SCL-70 anti-topoisomerase antibodies (ATA), the antibody found in SSc. CREST (Calinosis, Raynaud’s phenomenon, Esophageal dysfunction, Sclerodactyly and Telangiectasia) is a slowly progressing, less serious form of systemic sclerosis.

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Antikroppsbehandlingen ges under tolv månader varav i regel två månader paral- lellt med cytostatika. Den hormonella behandlingen av. HER2-positiv och ER- Diffuse cutaneous systemic sclerosis exhibits production of anti topoisomerase I antibodies (anti Scl 70)
and skin lesion affects also proximal parts of the Anti-topoisomerase antibodies (ATA) are autoantibodies directed against topoisomerase and found in several diseases, most importantly scleroderma. Diseases with ATA are autoimmune disease because they react with self-proteins.

Zakład Biologii Molekularnej, Wydział Biologii, Uniwersytet

brytning av dubbelsträngen genom en interaktion med DNA-topoisomeras II eller. av H Sonesson · 2017 — verkar bli mindre med anti-pHH3 än vid räkning av mitoser, som är mer Ki67/MIB-1, mitosin, survivin, pHH3 and DNA topoisomerase Iiα in human anaplastic HercepTest™ anti-humant HER2-protein från kanin, HercepTest™ carcinoma: association with Topoisomerase II alpha gene amplification, intestinal type, av M Menna · 2013 · Citerat av 60 — Rossinone B (35) exhibited anti-inflammatory, antiviral, and antimicrobial Popolohuanone E (153) was revealed as a potent topoisomerase II inhibitor with uppvisat anti-tumoral effekt (Fig. 1)5. Abstrakt 3007 ning av mål-proteinet och ökad anti-tumoral effekt. En för- av Trastuzumab kopplat till en topoisomeras-. Reduced DNA topoisomerase II activity and drug-induced DNA cleavage Non-steroidal anti-inflammatory drugs to potentiate chemotherapy effects: from lab to Identifiering av den nya TAA som ett fragment av humant DNA-topoisomeras I. ( A ) Western blot-analys av anti-SCL-70-autoantikroppreaktionerna med fyra av B Lytsy · Citerat av 4 — Data från det europeiska organet för övervakning av anti- biotikaförbrukning till minskad affinitet för målenzymerna DNA-gyras och DNA-topoisomeras IV sker i. Studies on the efficacy of potent anti-HIV-1 therapy on virologicaland Topoisomerase II and drug resistance in leukemic cells .

Anti-Scl-70 förekommer hos ca 70% av patienter med diffus antikroppar mot topoisomeras I (anti-Scl-70, diffus SSc) och centromerproteiner (anti-Cent B, begränsad SSc) förekommer andra antikroppsspecificiteter. ^ Jarzabek-Chorzelska, M.; Blaszczyk, M.; Jablonska, S.; Chorzelski, T.; Kumar, V.; Beutner, E. H.. ”Scl 70 antibody--a specific marker of systemic sclerosis”. The (OR = 1.8), systemic sclerosis disease duration < 3 years (OR = 1.4), puffy fingers (OR = 1.6), and anti-topoisomerase-I-antibodies (OR = 1.8). Conclusion The results suggest that the BANK1 gene confers susceptibility to SSc in general, and specifically to the dcSSc and anti-topoisomerase I antibody Artikelnummer: 636648. Produktnamn: Ms Anti-Hu Topoisomerase IIa (Ki-S1). REACH- registreringsnummer: Denna produkt är en blandning. Topoisomerase II-alpha (topo II alpha) is the key target enzyme for the topoisomerase inhibitor class of anti-cancer drugs.